Mexis^tm1.1Pton
Targeted Allele Detail

Summary

• Symbol: Mexis^tm1.1Pton
• Name: macrophage expressed LXRa(NR1H3)-dependent amplifier of Abca1 transcription lncRNA; targeted mutation 1.1, Peter Tontonoz
• MGI ID: MGI:6403491
• Synonyms: MeXis^-
• Gene: Mexis Location: Chr4:53261356-53270232 bp, - strand Genetic Position: Chr4, 28.6 cM
• Alliance: Mexis^tm1.1Pton page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264834
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One of the alternative exons 1 and invariant exon 2 were replaced with an FRT site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent flp-mediated recombination. (J:264834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mexis Mutation: 1 strain or line available

References

• Original: J:264834 Sallam T, et al., Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 Mar;24(3):304-312
• All: 1 reference(s)