Usp30^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Usp30^tm1.1Tac
• Name: ubiquitin specific peptidase 30; targeted mutation 1.1, Taconic
• MGI ID: MGI:6403637
• Synonyms: USP30 KO
• Gene: Usp30 Location: Chr5:114238395-114261571 bp, + strand Genetic Position: Chr5, 55.96 cM
• Alliance: Usp30^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286265
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into intron 1 and 2, and an FRT site flanked neomycin resistance gene cassette was also inserted into an intron. The targeting construct was injected into B6-Tyr ES cells along with cre recombinase. This results in a null allele lacking exon 2. (J:286265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp30 Mutation: 34 strains or lines available

References

• Original: J:286265 Phu L, et al., Dynamic Regulation of Mitochondrial Import by the Ubiquitin System. Mol Cell. 2020 Mar 5;77(5):1107-1123.e10
• All: 1 reference(s)