Kdm3b^tm1Jxu
Targeted Allele Detail

Summary

• Symbol: Kdm3b^tm1Jxu
• Name: KDM3B lysine (K)-specific demethylase 3B; targeted mutation 1, Jianming Xu
• MGI ID: MGI:6403638
• Synonyms: Kdm3b^-, Kdm3bKO
• Gene: Kdm3b Location: Chr18:34910100-34971713 bp, + strand Genetic Position: Chr18, 18.73 cM, cytoband B3
• Alliance: Kdm3b^tm1Jxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286338
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 15-23 were replaced with a neomycin selection cassette. Western blot analysis revealed the absence of protein expression in liver lysates, uteri and ovaries from homozygous mice. Immunohistochemical analysis confirmed the absence of protein in kidney epithelial cells, ovary, oviduct and uterus from homozygous mice. (J:286338)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm3b Mutation: 139 strains or lines available

References

• Original: J:286338 Liu Z, et al., The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function. Int J Biol Sci. 2015;11(5):494-507
• All: 2 reference(s)