Yap1^tm1.2Eno
Targeted Allele Detail

Summary

• Symbol: Yap1^tm1.2Eno
• Name: yes-associated protein 1; targeted mutation 1.2, Eric N Olson
• MGI ID: MGI:6403855
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm1.2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One loxP site was inserted in intron 2 while an FRT flanked PGK-neo selection cassette followed by a second loxP site was inserted in intron 3. Subsequent excision of the selection cassette left exon 3 flanked by loxP sites. Cre-mediated recombination removed exon 3. (J:284140)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 37 strains or lines available

References

• Original: J:284140 Frum T, et al., TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage. Development. 2019 Sep 6;146(17):dev179861
• All: 1 reference(s)