Chdh^em1Rmps
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chdh^em1Rmps
• Name: choline dehydrogenase; endonuclease-mediated mutation 1, Lab. for Molecular Psychiatry, RIKEN Center for Brain Science
• MGI ID: MGI:6403989
• Synonyms: Chdh^em1Tyrb
• Gene: Chdh Location: Chr14:29730957-29762423 bp, + strand Genetic Position: Chr14, 18.4 cM
• Alliance: Chdh^em1Rmps page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 43 bp deletion in exon 2. Western blot analysis confirmed absence of the protein in the kidney. (J:286033)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chdh Mutation: 37 strains or lines available

References

• Original: J:286033 Ohnishi T, et al., Investigation of betaine as a novel psychotherapeutic for schizophrenia. EBioMedicine. 2019 Jul;45:432-446
• All: 1 reference(s)