Fkrptm1.2Pg
Targeted Allele Detail
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Symbol: |
Fkrptm1.2Pg |
Name: |
fukutin related protein; targeted mutation 1.2, PolyGene AG |
MGI ID: |
MGI:6404019 |
Gene: |
Fkrp Location: Chr7:16543192-16550657 bp, - strand Genetic Position: Chr7, 9.15 cM
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Alliance: |
Fkrptm1.2Pg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:285924
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A leucine to isoleucine mutation at amino acid 276 was inserted into exon 3. In addition, a loxP site was inserted upstream of the exon, and a FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the neomycin selection cassette. Cre-mediated recombination deleted the mutated exon 3.
(J:285924)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fkrp Mutation: |
21 strains or lines available
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Original: |
J:285924 Krag TO, et al., A New Mouse Model of Limb-Girdle Muscular Dystrophy Type 2I Homozygous for the Common L276I Mutation Mimicking the Mild Phenotype in Humans. J Neuropathol Exp Neurol. 2015 Dec;74(12):1137-46 |
All: |
1 reference(s) |
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