Leat1^{Tg(Tyr)442Ove}
Transgenic Allele Detail

Summary

• Symbol: Leat1^{Tg(Tyr)442Ove}
• Name: lncRNA Efnb2 associated transcript 1; transgene insertion 442, Paul Overbeek
• MGI ID: MGI:6404110
• Synonyms: OVE442
• Gene: Leat1 Location: Chr8:8385077-8392428 bp, + strand Genetic Position: Chr8, 2.92 cM
• Alliance: Leat1^{Tg(Tyr)442Ove} page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 4.1 kb tyrosinase minigene (TYBS) transgene with the 2.1 kb BALB/c mouse Tyr promoter region and 2.0 kb Tyr cDNA sequence (including the stop codon polyA sequences) deleted a region 300 kb downstream of the EphrinB2 containing the long noncoding RNA. (J:284089)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Leat1 Mutation: 0 strains or lines available

References

• Original: J:284089 Mattiske D, et al., A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice. Differentiation. 2019 Dec 4;112:1-6
• All: 1 reference(s)