Parn^em1Ins
Endonuclease-mediated Allele Detail

Summary

• Symbol: Parn^em1Ins
• Name: poly(A)-specific ribonuclease (deadenylation nuclease); endonuclease-mediated mutation 1, INSERM
• MGI ID: MGI:6404379
• Synonyms: Parn^#25
• Gene: Parn Location: Chr16:13355828-13486035 bp, - strand Genetic Position: Chr16, 9.32 cM, cytoband B1
• Alliance: Parn^em1Ins page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 4 deleted 2 bp. (J:285666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parn Mutation: 55 strains or lines available

References

• Original: J:285666 Benyelles M, et al., Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. EMBO Mol Med. 2019 Jul;11(7):e10201
• All: 1 reference(s)