Ezhip^em1Marg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ezhip^em1Marg
• Name: EZH inhibitory protein; endonuclease-mediated mutation 1, Raphael Margueron
• MGI ID: MGI:6404408
• Gene: Ezhip Location: ChrX:5993273-5995473 bp, - strand Genetic Position: ChrX, 2.7 cM
• Alliance: Ezhip^em1Marg page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1.5-kb deletion spanning the locus. RT-PCR and Western blot analysis confirmed the absence of mRNA and protein in the testis and ovaries. Expression of the flanking genes Nudt10 and Nudt11 are unaffected. (J:281161)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ezhip Mutation: 11 strains or lines available

References

• Original: J:281161 Ragazzini R, et al., EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Nat Commun. 2019 Aug 26;10(1):3858
• All: 1 reference(s)