Mylip^tm1.1Pton
Targeted Allele Detail

Summary

• Symbol: Mylip^tm1.1Pton
• Name: myosin regulatory light chain interacting protein; targeted mutation 1.1, Peter Tontonoz
• MGI ID: MGI:6404434
• Synonyms: Idol^f
• Gene: Mylip Location: Chr13:45543218-45565498 bp, + strand Genetic Position: Chr13, 21.88 cM
• Alliance: Mylip^tm1.1Pton page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A cassette containing (5' to 3') a lox71 site, FRT site, loxP site, engrailed 2 splice acceptor, betal gal, neo resistance gene, polyadenylation sequence, and a second FRT site. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving leaving only exon 2 flanked by an upstream lox71 site and a downstream loxP site. (J:172834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mylip Mutation: 23 strains or lines available

Notes

ES cells = E14TG2a;D

References

• Original: J:172834 Scotti E, et al., Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol. 2011 May;31(9):1885-93
• All: 3 reference(s)