Tg(CAG-PCCA*A138T,-EGFP)#Miab
Transgene Detail

Summary

• Symbol: Tg(CAG-PCCA*A138T,-EGFP)#Miab
• Name: transgene insertion, Michael A Barry
• MGI ID: MGI:6404456
• Synonyms: Tg(CAG-PCCA*A138T,-EGFP)#Maba
• Transgene: Tg(CAG-PCCA*A138T,-EGFP)#Miab Location: unknown
• Alliance: Tg(CAG-PCCA*A138T,-EGFP)#Miab page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-PCCA*A138T,-EGFP)#Miab expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PCCA (5095)

  Pcca	(MGI:97499)

• Mutation details: The human PCCA cDNA containing an A to T mutation at position 138 in exon 5 and enhanced green fluorescent protein are under the control of the ubiquitously active CAG promoter. This mutation has been identified in propionic acidemia patients with mild to moderate symptoms. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:286218)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:286218 Guenzel AJ, et al., Generation of a hypomorphic model of propionic acidemia amenable to gene therapy testing. Mol Ther. 2013 Jul;21(7):1316-23
• All: 6 reference(s)