Cyp2c^{tm1897.1(Alb-CYP2C9)Arte}
Targeted Allele Detail

Summary

• Symbol: Cyp2c^{tm1897.1(Alb-CYP2C9)Arte}
• Name: cytochrome P450, family 2, subfamily c cluster; targeted mutation 1897.1, TaconicArtemis
• MGI ID: MGI:6404560
• Synonyms: Cyp2c^{tm1897(albCYP2C9)Arte}, hCYP2C9, Is(19Alb/CYP2C9;Del19Cyp2c55-Cyp2c70)2Arte
• Gene: Cyp2c Location: unknown Genetic Position: Chr19, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241121
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Deletion, Insertion
• Cyp2c^{tm1897.1(Alb-CYP2C9)Arte} involves 19 genes/genome features (Gm23800, Cyp2c55, Gm3875 ...) View all
• Cyp2c^{tm1897.1(Alb-CYP2C9)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP2C9 (1559)

  Cyp2c29	(MGI:103238)
  Cyp2c37	(MGI:1306806)
  Cyp2c38	(MGI:1306819)
  Cyp2c39	(MGI:1306818)
  Cyp2c50	(MGI:2147497)
  Cyp2c65	(MGI:1919553)
  Cyp2c66	(MGI:1917138)

• Mutation details: Cre-recombination in ES cells containing Cyp2c^tm1Wolf inserted the human sequence corresponding to human CYP2C9 exons 1 through 4, intron 4, and exons 5 through 9 linked to a fusion of the 8.5-10.4 kb BamHI/NheI enhancer and 0.3 kb promoter fragment of the mouse albumin upstream regulatory region. Flp-mediated recombination removed the selection cassette. (J:241121)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2c Mutation: 0 strains or lines available

References

• Original: J:241121 Scheer N, et al., Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines. Mol Pharmacol. 2012 Dec;82(6):1022-9
• All: 3 reference(s)