Cyp1a^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Cyp1a^tm1Arte
• Name: cytochrome P450, family 1, subfamily a cluster; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:6405048
• Gene: Cyp1a Location: unknown Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278424
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cyp1a^tm1Arte involves 2 genes/genome features (Cyp1a2, Cyp1a1) View all
• Mutation details: Cre-mediated recombination between Cyp1a1^{tm2025.1(CYP1A1)Arte} and Cyp1a2^{tm2024.1(CYP1A2)Arte} deleted both coding sequences and their humanized replacement sequences. (J:278424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp1a Mutation: 0 strains or lines available

References

• Original: J:278424 Kapelyukh Y, et al., Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice. Drug Metab Dispos. 2019 Aug;47(8):907-918
• All: 2 reference(s)