Tardbptm1.1Neas
Targeted Allele Detail
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Symbol: |
Tardbptm1.1Neas |
Name: |
TAR DNA binding protein; targeted mutation 1.1, Neil A Shneider |
MGI ID: |
MGI:6405194 |
Synonyms: |
TDP-43M337V |
Gene: |
Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
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Alliance: |
Tardbptm1.1Neas page
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Germline Transmission: |
Earliest citation of germline transmission:
J:283769
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A methionine to valine substitution at amino acid 337 was introduced into exon 6 along with a FRT-flanked neomycin resistance cassette via homologous recombination. Flp-mediated recombination removed the neo selection cassette. The M337V mutation is one of the most common amyotrophic lateral sclerosis-associated mutations. TARDBP remains nuclear in homozygous mice.
(J:283769)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tardbp Mutation: |
68 strains or lines available
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Original: |
J:283769 Ebstein SY, et al., Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS. Cell Rep. 2019 Jan 8;26(2):364-373.e4 |
All: |
1 reference(s) |
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