Tfrc^Rbc6
Chemically induced Allele Detail

Summary

• Symbol: Tfrc^Rbc6
• Name: transferrin receptor; red blood cell mutant 6
• MGI ID: MGI:6406247
• Synonyms: tfrc^L645R
• Gene: Tfrc Location: Chr16:32427738-32451612 bp, + strand Genetic Position: Chr16, 23.06 cM
• Alliance: Tfrc^Rbc6 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G point mutation that results in the amino acid substitution of arginine for leucine at position 645 (L645R). (J:285514)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfrc Mutation: 62 strains or lines available

References

• Original: J:285514 Conway AJ, et al., Characterization of Tfrc-mutant mice with microcytic phenotypes. Blood Adv. 2018 Aug 14;2(15):1914-1922
• All: 2 reference(s)