Ace2^em1Shyy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1Shyy
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, John Y J Shyy
• MGI ID: MGI:6406963
• Synonyms: Ace2KO
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1Shyy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A frameshift mutation was introduced by CRISPR genome editing technology. No further details are provided. (J:286356)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:286356 Zhang J, et al., AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 Aug 15;198(4):509-520
• All: 1 reference(s)