Scn2a^tm1.1Csbd
Targeted Allele Detail

Summary

• Symbol: Scn2a^tm1.1Csbd
• Name: sodium channel, voltage-gated, type II, alpha; targeted mutation 1.1, Eunjoon Kim
• MGI ID: MGI:6407390
• Synonyms: Scn2a^f, Scn2a^tm1.1Bcgen
• Gene: Scn2a Location: Chr2:65451115-65597791 bp, + strand Genetic Position: Chr2, 38.61 cM
• Alliance: Scn2a^tm1.1Csbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279152
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site, EGFP, loxP site, neomycin selection gene, FRT site and loxP site were inserted upstream of exon 4 and a third loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the EGFP and neomycin genes, leaving exons 4-6 floxed. (J:279152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn2a Mutation: 92 strains or lines available

References

• Original: J:279152 Shin W, et al., Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory. Front Mol Neurosci. 2019;12:145
• All: 2 reference(s)