Tdp1^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tdp1^em1(IMPC)Tcp
• Name: tyrosyl-DNA phosphodiesterase 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:6414506
• Gene: Tdp1 Location: Chr12:99850776-99921478 bp, + strand Genetic Position: Chr12, Syntenic
• Alliance: Tdp1^em1(IMPC)Tcp page
• IMPC: Tdp1 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project TCPR1537 was generated at The Centre for Phenogenomics by electroporatingCas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of AATTCCGTGATGGGAGTTGT targeting the 5' side and ACAGGGCTTTTGTCGGATCT targeting the 3' side of a critical region. This resulted in a 1137-bp deletion; Chr12:99909519-99910655 (GRCm38). (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tdp1 Mutation: 53 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 3 reference(s)