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Eny2em1(IMPC)Bay
Endonuclease-mediated Allele Detail
Summary
Symbol: Eny2em1(IMPC)Bay
Name: ENY2 transcription and export complex 2 subunit; endonuclease-mediated mutation 1, Baylor College of Medicine
MGI ID: MGI:6414562
Synonyms: Eny2-
Gene: Eny2  Location: Chr15:44291488-44301652 bp, + strand  Genetic Position: Chr15, 16.91 cM
Alliance: Eny2em1(IMPC)Bay page
IMPC: Eny2 gene page
Eny2em1(IMPC)Bay/Eny2em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form irregular outgrowths with no obvious inner cell mass colony or trophoblast giant cells.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from IMPC was generated at Bayor College of Medicine by injecting CAS9 Protein and 4 guide sequences GAACTGTGTTTAATTACCTCAGG, ACAGCTGGAGAATATTACCCAGG, TTAGGTACATAAGTGCTTAATGG, TTGTGTCATTAGAGCAAATTTGG, which resulted in a Exon Deletion. (J:265051)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eny2 Mutation:  8 strains or lines available
References
Original:  J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory