Rexo1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rexo1^em1(IMPC)J
• Name: REX1, RNA exonuclease 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6414770
• Gene: Rexo1 Location: Chr10:80376756-80397394 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Rexo1^em1(IMPC)J page
• IMPC: Rexo1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GTATGAGAGGAAGCAGCGCT and CATTGCCGCCAGACCCTACG, which resulted in a 917 bp deletion beginning at Chromosome 10 position 80,547,705 bp and ending after 80,548,621 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001237652 and ENSMUSE00001289454 (exons 3 and 4) and 601 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 632 and early truncation 24 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rexo1 Mutation: 36 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)