Wnk4^em1Cjc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wnk4^em1Cjc
• Name: WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 1, Chih-Jen Cheng
• MGI ID: MGI:6414871
• Synonyms: L319F/L321F WNK4 KI
• Gene: Wnk4 Location: Chr11:101151393-101168235 bp, + strand Genetic Position: Chr11, 64.51 cM
• Alliance: Wnk4^em1Cjc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-Cas9 technology generated a CTC to TTC change resulting in a leucine to phenylalanine substitution at amino acid 319 and a CTG to TTC change resulting in a leucine to phenylalanine substitution at amino acid 321. The L319F/L321F mutations result in a chloride-insensitive WNK4. (J:274218)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk4 Mutation: 58 strains or lines available

References

• Original: J:274218 Chen JC, et al., WNK4 kinase is a physiological intracellular chloride sensor. Proc Natl Acad Sci U S A. 2019 Feb 14
• All: 1 reference(s)