H3c2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: H3c2^tm1Mak
• Name: H3 clustered histone 2; targeted mutation 1, Tak W Mak
• MGI ID: MGI:6414914
• Synonyms: Hist1h3b^K27M
• Gene: H3c2 Location: Chr13:23936328-23936823 bp, + strand Genetic Position: Chr13, 9.91 cM, cytoband A2-A3
• Alliance: H3c2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285841
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A lysine to methionine substitution at amino acid 28 was introduced into the single exon. An FRT-flanked neomycin resistance cassette was also inserted. (J:285841)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H3c2 Mutation: 7 strains or lines available

References

• Original: J:285841 Fortin J, et al., Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Cancer Cell. 2020 Mar 16;37(3):308-323.e12
• All: 1 reference(s)