Cntnap4^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cntnap4^em1Smoc
• Name: contactin associated protein-like 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6415695
• Gene: Cntnap4 Location: Chr8:113296675-113609349 bp, + strand Genetic Position: Chr8, 58.7 cM
• Alliance: Cntnap4^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a deletion of exon 3. Western blot analysis confirmed absence of protein. (J:287186)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cntnap4 Mutation: 70 strains or lines available

References

• Original: J:287186 Zhang W, et al., CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Theranostics. 2020;10(7):3000-3021
• All: 3 reference(s)