Ifnlr1tm1b(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Ifnlr1tm1b(EUCOMM)Wtsi |
Name: |
interferon lambda receptor 1; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6416070 |
Gene: |
Ifnlr1 Location: Chr4:135413598-135435492 bp, + strand Genetic Position: Chr4, 67.94 cM
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Alliance: |
Ifnlr1tm1b(EUCOMM)Wtsi page
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IMPC: |
Ifnlr1 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:240624
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Parent Cell Line: |
JM8A3.N1.C2 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 135416791 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 135418289. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:240624)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ifnlr1 Mutation: |
37 strains or lines available
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Original: |
J:240624 Baldridge MT, et al., Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus. J Virol. 2017 Apr 01;91(7) |
All: |
9 reference(s) |
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