Hoatz^em1Seta
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoatz^em1Seta
• Name: HOATZ cilia and flagella associated protein; endonuclease-mediated mutation 1, Sen Takeda
• MGI ID: MGI:6416172
• Synonyms: Hoatz^-, Hoatzin^-
• Gene: Hoatz Location: Chr9:50992415-51013378 bp, - strand Genetic Position: Chr9, 27.81 cM, cytoband B
• Alliance: Hoatz^em1Seta page

Mutation origin

• Strain of Origin: (C57BL/6 X DBA/2)F1 x C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 1 generated a 114-nucleotide deletion around the target sequence and a 381-nucleotide insertion downstream of the target sequence. Western blot analysis confirmed absence of protein in testis extracts. (J:287082)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoatz Mutation: 10 strains or lines available

References

• Original: J:287082 Narita K, et al., Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis. iScience. 2020 Mar 19;23(4):100992
• All: 1 reference(s)