Adnp^em1Ant
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adnp^em1Ant
• Name: activity-dependent neuroprotective protein; endonuclease-mediated mutation 1, Frank Kooy
• MGI ID: MGI:6416397
• Gene: Adnp Location: Chr2:168022906-168049032 bp, - strand Genetic Position: Chr2, 88.41 cM
• Alliance: Adnp^em1Ant page

Mutation origin

• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing introduced a 14 nucleotide deletion such that Leucine822 is replaced by Histidine and followed by 6 amino acids and a termination codon in exon 5. The deletion causes a frameshift and is predicted to result in a truncated protein.

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adnp Mutation: 96 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)