Cyp4f39^em1Akih
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp4f39^em1Akih
• Name: cytochrome P450, family 4, subfamily f, polypeptide 39; endonuclease-mediated mutation 1, Akio Kihara
• MGI ID: MGI:6423306
• Gene: Cyp4f39 Location: Chr17:32671697-32712294 bp, + strand Genetic Position: Chr17, 17.59 cM
• Alliance: Cyp4f39^em1Akih page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 11 produced a 32 bp framshift deletion. (J:286705)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp4f39 Mutation: 41 strains or lines available

References

• Original: J:286705 Miyamoto M, et al., Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production. J Invest Dermatol. 2020 Feb;140(2):319-326.e4
• All: 4 reference(s)