Slxl1^em1.1Jbmu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slxl1^em1.1Jbmu
• Name: Slx-like 1; endonuclease-mediated mutation 1.1, Jacob Mueller
• MGI ID: MGI:6423420
• Gene: Slxl1 Location: ChrX:54272236-54289083 bp, + strand Genetic Position: ChrX, 30.06 cM
• Alliance: Slxl1^em1.1Jbmu page

Mutation origin

• Strain of Origin: mixed

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: To generate mice with multi-megabase deletion of Slxl1 ampliconic region, loxP sites were sequentially integrated upstream and downstream of the Slx ampliconic region via CRISPR. Cre-mediated deletion deleted the floxed allele. (J:304511)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slxl1 Mutation: 4 strains or lines available

Notes

Zygotes were derived from a cross of (C57BL/6NHsd x DBA/2NHsd)F1 and C57BL/6NHsd.

References

• Original: J:304511 Kruger AN, et al., A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice. Curr Biol. 2019 Nov 4;29(21):3699-3706.e5
• All: 2 reference(s)