Aldh1a1^{tm1.1(cre/ERT2)Cai}
Targeted Allele Detail

Summary

• Symbol: Aldh1a1^{tm1.1(cre/ERT2)Cai}
• Name: aldehyde dehydrogenase family 1, subfamily A1; targeted mutation 1.1, Huaibin Cai
• MGI ID: MGI:6423547
• Synonyms: Aldh1a1^P2A-CreERT2
• Gene: Aldh1a1 Location: Chr19:20470079-20620829 bp, + strand Genetic Position: Chr19, 13.91 cM
• Alliance: Aldh1a1^{tm1.1(cre/ERT2)Cai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280705
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Aldh1a1^{tm1.1(cre/ERT2)Cai} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aldh1a1 (MGI:1353450)

• Mutation details: The targeting construct "pDNDF-7-DTA-5 arm-P2A-CreERT2-STOP-Frt-Neo-Frt-3 arm-DTA" replaced the stop codon. Flp-mediated recombination removed the selection cassette. (J:280705)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1a1 (mouse) Summary of all recombinase alleles driven by Aldh1a1. Comparative matrix view of recombinase activities Alliance mouse Aldh1a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1a1 Mutation: 39 strains or lines available

References

• Original: J:280705 Wu J, et al., Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Rep. 2019 Jul 30;28(5):1167-1181.e7
• All: 2 reference(s)