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Stk39tm1Pawe
Targeted Allele Detail
Summary
Symbol: Stk39tm1Pawe
Name: serine/threonine kinase 39; targeted mutation 1, Paul A Welling
MGI ID: MGI:6423627
Synonyms: floxed CA-SPAK
Gene: Stk39  Location: Chr2:68040789-68302381 bp, - strand  Genetic Position: Chr2, 39.53 cM, cytoband C3
Alliance: Stk39tm1Pawe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:287773
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP flanked PGK-neomycin selection cassette and an HA-tagged Stk39 cDNA containing two mutations, a threonine to glutamate change at residue 243 (T243E) and a serine to aspartate change at 383 (S383D) and an in-frame stop codon were inserted after the start codon of Stk39. These two mutations generate a constitutively active kinase. In the absence of cre-recombinase, the cassette renders the native gene inactive and generates a null allele. (J:287773)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk39 Mutation:  42 strains or lines available
References
Original:  J:287773 Grimm PR, et al., Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. J Am Soc Nephrol. 2017 Sep;28(9):2597-2606
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory