Stk39tm1.1Pawe
Targeted Allele Detail
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Symbol: |
Stk39tm1.1Pawe |
Name: |
serine/threonine kinase 39; targeted mutation 1.1, Paul A Wellling |
MGI ID: |
MGI:6423628 |
Gene: |
Stk39 Location: Chr2:68040789-68302381 bp, - strand Genetic Position: Chr2, 39.53 cM, cytoband C3
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Alliance: |
Stk39tm1.1Pawe page
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Germline Transmission: |
Earliest citation of germline transmission:
J:287773
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Constitutively active, Epitope tag) |
Mutation: |
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Nucleotide substitutions
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Mutation details: A loxP flanked PGK-neomycin selection cassette and an HA-tagged Stk39 cDNA containing two mutations, a threonine to glutamate change at residue 243 (T243E) and a serine to aspartate change at 383 (S383D), and an in-frame stop codon were inserted after the start codon of Stk39. Cre-mediated recombination excised the selection cassette resulting in expression of the constitutively active kinase under the control of the native gene promoter.
(J:287773)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Stk39 Mutation: |
42 strains or lines available
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Original: |
J:287773 Grimm PR, et al., Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. J Am Soc Nephrol. 2017 Sep;28(9):2597-2606 |
All: |
1 reference(s) |
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