Kprp^tm1Msug
Targeted Allele Detail

Summary

• Symbol: Kprp^tm1Msug
• Name: keratinocyte expressed, proline-rich; targeted mutation 1, Makoto Sugaya
• MGI ID: MGI:6429935
• Gene: Kprp Location: Chr3:92730381-92734554 bp, - strand Genetic Position: Chr3, 40.14 cM, cytoband F2
• Alliance: Kprp^tm1Msug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced part of exon 2 containing the start codon. Western blot analysis confirmed the absence of protein. (J:286659)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kprp Mutation: 39 strains or lines available

References

• Original: J:286659 Suga H, et al., Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis Leads to Barrier Disruption. J Invest Dermatol. 2019 Sep;139(9):1867-1875.e7
• All: 1 reference(s)