Clu^{em2(dre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clu^{em2(dre/ERT2)Smoc}
• Name: clusterin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:6430708
• Synonyms: Clu-2A-DreER, Clu^{em2(2A-DreERT2)Smoc}
• Gene: Clu Location: Chr14:66206093-66218992 bp, + strand Genetic Position: Chr14, 34.36 cM
• Alliance: Clu^{em2(dre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Clu^{em2(dre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Clu (MGI:88423)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a viral 2A oligopeptide that mediates ribosomal skipping and a Dre/ERT2 fusion recombinase gene cassette into the gene stop codon. (J:238766, J:304636)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Clu (mouse) Summary of all recombinase alleles driven by Clu. Alliance mouse Clu gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clu Mutation: 32 strains or lines available

References

• Original: J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2
• All: 2 reference(s)