Rcbtb2^tm1.1Xyw
Targeted Allele Detail

Summary

• Symbol: Rcbtb2^tm1.1Xyw
• Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2; targeted mutation 1.1, Xiao-Yan Wen
• MGI ID: MGI:6431098
• Gene: Rcbtb2 Location: Chr14:73376185-73421495 bp, + strand Genetic Position: Chr14, 38.66 cM
• Alliance: Rcbtb2^tm1.1Xyw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Cre mediated recombination removed exons 4 and 5 and the neo cassette. (J:282928)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rcbtb2^tm1.1Xyw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcbtb2 Mutation: 35 strains or lines available

References

• Original: J:282928 Spillane DR, et al., Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor Involved in Development of Histiocyte-Rich Neoplasms. PLoS One. 2015;10(8):e0135755
• All: 1 reference(s)