Cfap69^em1Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cfap69^em1Fzh
• Name: cilia and flagella associated protein 69; endonuclease-mediated mutation 1, Feng Zhang
• MGI ID: MGI:6431857
• Gene: Cfap69 Location: Chr5:5629284-5714232 bp, - strand Genetic Position: Chr5, 3.07 cM
• Alliance: Cfap69^em1Fzh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 2-4, resulting in a frameshift mutation. (J:288345)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfap69 Mutation: 58 strains or lines available

References

• Original: J:288345 He X, et al., Novel homozygous CFAP69 mutations in humans and mice cause severe asthenoteratospermia with multiple morphological abnormalities of the sperm flagella. J Med Genet. 2019 Feb;56(2):96-103
• All: 2 reference(s)