Wdfy3^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Wdfy3^{Tn(pb-Act-RFP)1.1Zhu}
• Name: WD repeat and FYVE domain containing 3; transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:6433103
• Synonyms: Wdfy3^PB
• Gene: Wdfy3 Location: Chr5:101980822-102217787 bp, - strand Genetic Position: Chr5, 48.95 cM
• Alliance: Wdfy3^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Null/knockout, Reporter)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. Line 1 contains a transposon inserted into intron 23 of the gene in reverse orientation. Western blot analysis confirmed the absence of protein expression in the heart and other organs, such as brain, of homozygous mutant embryos. (J:285853)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdfy3 Mutation: 210 strains or lines available

References

• Original: J:285853 Zhang S, et al., WD40 repeat and FYVE domain containing 3 is essential for cardiac development. Cardiovasc Res. 2019 Jul 1;115(8):1320-1331
• All: 2 reference(s)