Vipr2^em1Litt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vipr2^em1Litt
• Name: vasoactive intestinal peptide receptor 2; endonuclease-mediated mutation 1, Dan R Littman
• MGI ID: MGI:6436298
• Synonyms: Vipr2^fl
• Gene: Vipr2 Location: Chr12:116041346-116109881 bp, + strand Genetic Position: Chr12, 62.59 cM, cytoband F2
• Alliance: Vipr2^em1Litt page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce loxP sites on either side of the exons 3-4. Resultant mice were sequenced to identify mice homozygous for both loxP insertions. (J:289029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vipr2 Mutation: 31 strains or lines available

References

• Original: J:289029 Talbot J, et al., Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier. Nature. 2020 Mar;579(7800):575-580
• All: 1 reference(s)