Tmem95^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem95^em1Osb
• Name: transmembrane protein 95; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6437561
• Synonyms: Tmem95 del
• Gene: Tmem95 Location: Chr11:69766883-69768879 bp, - strand Genetic Position: Chr11, 42.91 cM
• Alliance: Tmem95^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting the intron upstream of the first coding exon and the 3' untranslated region of the last exon generated a 1,919 bp deletion. (J:289149)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tmem95 Mutation: 9 strains or lines available

References

• Original: J:289149 Noda T, et al., Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502
• All: 3 reference(s)