Spaca6^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Spaca6^em2Osb
• Name: sperm acrosome associated 6; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6437562
• Synonyms: Spaca6 del
• Gene: Spaca6 Location: Chr17:18047420-18063271 bp, + strand Genetic Position: Chr17, 10.5 cM, cytoband A3.1
• Alliance: Spaca6^em2Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting the first coding exon and the intron downstream of the last coding exon generated an 8,085 bp deletion and a 4 bp insertion. (J:289149)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Spaca6 Mutation: 37 strains or lines available

References

• Original: J:289149 Noda T, et al., Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502
• All: 2 reference(s)