Cdon^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Cdon^{tm1c(EUCOMM)Hmgu}
• Name: cell adhesion molecule-related/down-regulated by oncogenes; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6441028
• Synonyms: Cdon^fl, Cdon^tm3cRsk
• Gene: Cdon Location: Chr9:35332836-35418948 bp, + strand Genetic Position: Chr9, 20.24 cM
• Alliance: Cdon^{tm1c(EUCOMM)Hmgu} page
• IMPC: Cdon gene page

Mutation origin

• Mutant Cell Lines: HEPD0610_4_C03, HEPD0610_4_H02
• Germline Transmission: Earliest citation of germline transmission: J:289968
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 35380682 of Chromosome 9 upstream of the critical exon 8 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon at position 35381736. The critical exon 8 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:289968)

Expression

In Mice Carrying this Mutation:

68 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdon Mutation: 66 strains or lines available

References

• Original: J:289968 Bae J-H, et al., Satellite Cell-Specific Ablation of Cdon Impairs Integrin Activation, FGF Signalling, and Muscle Regeneration. J Cachexia Sarcopenia Muscle. 2020
• All: 4 reference(s)