Slc38a1^tm1.1Ttaka
Targeted Allele Detail

Summary

• Symbol: Slc38a1^tm1.1Ttaka
• Name: solute carrier family 38, member 1; targeted mutation 1.1, Takeshi Takarada
• MGI ID: MGI:6441049
• Synonyms: Slc38a1^flox
• Gene: Slc38a1 Location: Chr15:96469299-96540794 bp, - strand Genetic Position: Chr15, 52.53 cM
• Alliance: Slc38a1^tm1.1Ttaka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288818
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 1, and a second loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a consitional-ready allele with exon 2 floxed. (J:288818)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc38a1 Mutation: 32 strains or lines available

References

• Original: J:288818 Yamada D, et al., Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system. Commun Biol. 2019;2:346
• All: 1 reference(s)