Card14^em2Tshu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Card14^em2Tshu
• Name: caspase recruitment domain family, member 14; endonuclease-mediated mutation 2, Tsinghua University
• MGI ID: MGI:6441136
• Synonyms: Carma2^E138A
• Gene: Card14 Location: Chr11:119198594-119236201 bp, + strand Genetic Position: Chr11, 83.36 cM
• Alliance: Card14^em2Tshu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Constitutively active)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated an A to C nucleotide change at position 413 resulting in a glutamate to alanine change at amino acid 138 (p.Glu138Ala). (J:289239)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card14 Mutation: 40 strains or lines available

References

• Original: J:289239 Wang M, et al., Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A. Immunity. 2018 Jul 17;49(1):66-79.e5
• All: 1 reference(s)