Rabl3^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rabl3^em1Btlr
• Name: RAB, member RAS oncogene family-like 3; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6441477
• Synonyms: mRABL3^-
• Gene: Rabl3 Location: Chr16:37360247-37392747 bp, + strand Genetic Position: Chr16, 26.39 cM
• Alliance: Rabl3^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: This knock-out mutation was created using CRISPR/Cas9 technology with sgRNA 5'-GATTTCCTAACACTTGATTG-3' in the conserved G2 motif. (J:287198)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rabl3 Mutation: 18 strains or lines available

References

• Original: J:287198 Zhong X, et al., Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8563-8572
• All: 1 reference(s)