Tbx6^em3Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbx6^em3Fzh
• Name: T-box 6; endonuclease-mediated mutation 3, Feng Zhang
• MGI ID: MGI:6441961
• Synonyms: Tbx6^up3
• Gene: Tbx6 Location: Chr7:126380655-126384720 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Tbx6^em3Fzh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 47 bp deletion in the 5' regulatory region (chr7:126781201-126781247, GRCm38/mm10) of Tbx6. qRT-PCR and RNA in situ hybridization indicate that Tbx6 RNA expression is elevated. (J:288810)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx6 Mutation: 17 strains or lines available

References

• Original: J:288810 Ren X, et al., Increased TBX6 gene dosages induce congenital cervical vertebral malformations in humans and mice. J Med Genet. 2020 Jun;57(6):371-379
• All: 1 reference(s)