About   Help   FAQ
Tg(Tk1-DPP4)27Ysj
Transgene Detail
Summary
Symbol: Tg(Tk1-DPP4)27Ysj
Name: transgene insertion 27, Yong-Suk Jang
MGI ID: MGI:6443611
Synonyms: hDPP4-Tg
Transgene: Tg(Tk1-DPP4)27Ysj  Location: unknown  
Alliance: Tg(Tk1-DPP4)27Ysj page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tk1-DPP4)27Ysj expresses 1 gene
 
Mutation detailsThe full-length human DPP4 cDNA with an N-terminal Flag tag is under the control of the thymidine kinase promoter. Four lines were established: 2, 10, 17 and 27. This is the highest expressing line with high fertility. Western blot analysis confirmed expression in brain, liver, lung, and intestine. (J:290259)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
tg1  Disease Model
involves: C57BL/6 * FVB/N
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
behavior/neurological
decreased locomotor activity
convulsive seizures
cardiovascular system
lung hemorrhage
growth/size/body
increased susceptibility to weight loss
hematopoietic system
abnormal macrophage activation involved in immune response
homeostasis/metabolism
abnormal chemokine level
abnormal interleukin level
abnormal tumor necrosis factor level
increased transforming growth factor beta level
immune system
abnormal chemokine level
abnormal interleukin level
abnormal tumor necrosis factor level
lung inflammation
abnormal innate immunity
abnormal macrophage activation involved in immune response
increased susceptibility to Coronaviridae infection
increased susceptibility to Coronaviridae infection induced morbidity/mortality
integument
ruffled hair
mortality/aging
increased susceptibility to Coronaviridae infection induced morbidity/mortality
nervous system
convulsive seizures
respiratory system
lung hemorrhage
lung inflammation
abnormal lung morphology
pulmonary fibrosis
hyperpnea
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
tg1
IDs
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:290259 Kim J, et al., Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory