Klk6^tm1Gsot
Targeted Allele Detail

Summary

• Symbol: Klk6^tm1Gsot
• Name: kallikrein related-peptidase 6; targeted mutation 1, Georgia Sotiropoulou
• MGI ID: MGI:6444221
• Gene: Klk6 Location: Chr7:43473967-43481219 bp, + strand Genetic Position: Chr7, 28.28 cM, cytoband B4-B5
• Alliance: Klk6^tm1Gsot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 and were replaced with a universal docking site cassette. The cassette is composed of a splice acceptor IRES-Beta geo-lacZ sequence, a loxP site, followed by the deltaTK and neomycin under the control of the human beta-actin promoter, a second loxP site, a PhiC31 attP site and a puromycin sequence that is not active unless a promoter is inserted by PhiC31 at the attP site. (J:270051, J:290434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klk6 Mutation: 27 strains or lines available

References

• Original: J:290434 Pampalakis G, et al., KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species. Oncotarget. 2017 Feb 28;8(9):14502-14515
• All: 3 reference(s)