Fis1^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Fis1^tm1.1Itl
• Name: fission, mitochondrial 1; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:6444618
• Synonyms: Fis1^FL
• Gene: Fis1 Location: Chr5:136982129-136995088 bp, + strand Genetic Position: Chr5, 76.06 cM, cytoband G1
• Alliance: Fis1^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290485
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 2 through 4 floxed. (J:290485)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fis1 Mutation: 47 strains or lines available

References

• Original: J:290485 Zhang Z, et al., Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle. Mitochondrion. 2019 Nov;49:217-226
• All: 1 reference(s)