Cyrib^m1Ivdi
Chemically induced Allele Detail

Summary

• Symbol: Cyrib^m1Ivdi
• Name: CYFIP related Rac1 interactor B; mutation 1, Ivan Dikic
• MGI ID: MGI:6444806
• Synonyms: Ity15^m
• Gene: Cyrib Location: Chr15:63800946-63932327 bp, - strand Genetic Position: Chr15, 28.16 cM
• Alliance: Cyrib^m1Ivdi page

Mutation origin

• Strain of Origin: 129S1

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis resulted in a T-to-A mutation in the second base of intron 9, affecting the exon 9 splice donor site. This results in mis-splicing with skipping of exon 9. (J:282597)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyrib Mutation: 88 strains or lines available

References

• Original: J:282597 Yuki KE, et al., CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol. 2019 Sep;4(9):1516-1531
• All: 1 reference(s)