Ctrc^m1
Spontaneous Allele Detail

Summary

• Symbol: Ctrc^m1
• Name: chymotrypsin C; mutation 1
• MGI ID: MGI:6446748
• Gene: Ctrc Location: Chr4:141565550-141573598 bp, - strand Genetic Position: Chr4, 74.75 cM
• Alliance: Ctrc^m1 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This spontaneous mutation is the minor variant of SNP rs221612964 that lacks the A in the TATT sequence, resulting in TTT in exon 2. This results in a non-functional gene that is found only in the C57BL/6 strain. All other 16 strains tested have the TATT sequence which yields a functional gene. (J:291240)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctrc Mutation: 23 strains or lines available

References

• Original: J:291240 Geisz A, et al., Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice. JCI Insight. 2019 Jul 25;4(14):e129717
• All: 1 reference(s)