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Gab3em1Khoe
Endonuclease-mediated Allele Detail
Summary
Symbol: Gab3em1Khoe
Name: growth factor receptor bound protein 2-associated protein 3; endonuclease-mediated mutation 1, Kasper Hoebe
MGI ID: MGI:6446855
Synonyms: Gab3KO
Gene: Gab3  Location: ChrX:74032151-74128511 bp, - strand  Genetic Position: ChrX, 38.12 cM
Alliance: Gab3em1Khoe page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was targeted with three shRNA guide sequences (5'-ACACTATCTGGAGTCACTTA-3', 5'-CTACCTAGTAGCCAAGACTG-3', 5'-AGTCATCTGGAAGATGGTGC-3') using CRISPR/Cas9 technology. One founder mouse presented with an insertion of a G nucleotide in exon 2 (c.301_302insG), causing a frameshift and premature termination. (J:291290)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gab3 Mutation:  8 strains or lines available
References
Original:  J:291290 Sliz A, et al., Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Sci Immunol. 2019 Aug 2;4(38)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory